Oxidative stress-A key determinant of complications and negative outcome in hepatitis E virus infected pregnancies: A comprehensive account involving cases from northeast IndiaArticle Published on 2023-02-012023-06-12 Journal: Journal of medical virology [Category] E형 간염, [키워드] antioxidant fetal death HEV Pregnancy preterm. ROS [DOI] 10.1002/jmv.28576 PMC 바로가기
Preclinical efficacy and safety of novel SNAT against SARS-CoV-2 using a hamster modelArticle Published on 2022-12-012022-11-15 Journal: Drug delivery and translational research [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome antioxidant Antiviral antiviral drug Antiviral drug candidate assays Body weight loss coronavirus COVID-19 demonstrated Efficacy Efficacy and safety Epidemic fibroblast global public health hamsters Health Histopathology human cells human lung epithelium IMPROVE Inhaled inhaler LDH lipid peroxidation lung MDA Nanotechnology oral swabs other respiratory virus pandemic platform Preclinical reduce SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected hamsters silver nanoparticle SmaRT SNAT. tested virus load virus titer [DOI] 10.1007/s13346-022-01166-x PMC 바로가기
Association of trace element status in COVID-19 patients with disease severityResearch article Published on 2022-12-012022-10-05 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 변종, [키워드] Anti-inflammatory antioxidant clinical condition clinical symptom conditions coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 severity Critical Cu death died disease severity evaluated Fe four group groups I immune response immune system Infection Mg Mild symptom new SARS-CoV-2 no difference Patient reduce risk SARS-COV-2 infection Se Serum level severity severity of symptoms shown significant difference the patient Trace element trace elements Zn [DOI] 10.1016/j.jtemb.2022.127055 [Article Type] Research article
The role of berberine in Covid-19: potential adjunct therapyReview Published on 2022-12-012023-07-10 Journal: Inflammopharmacology [Category] COVID19(2023년), [키워드] Anti-inflammatory antioxidant Antiviral COVID-19 Immune-regulatory effects Inflammatory signaling pathways. [DOI] 10.1007/s10787-022-01080-1 PMC 바로가기 [Article Type] Review
Evaluation of the Relationship Between Aquaporin-1, Hepcidin, Zinc, Copper, and İron Levels and Oxidative Stress in the Serum of Critically Ill Patients with COVID-19Article Published on 2022-12-012022-11-16 Journal: Biological trace element research [Category] COVID19(2023년), SARS, 치료기술, [키워드] antioxidant aquaporin both groups chronic disease control group copper correlation COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients determine disease severity elements Endotracheal intubation had no healthy hepcidin Ill in viral indicated individual Infection Inpatient intensive care Invasive mechanical ventilation Level negative PCR test oxidative stress parameter patients with COVID-19 relationship Result SARS-CoV-2 separated sera Significant statistically significant TAC the healthy the patient Total Total antioxidant status Total oxidant status trace Trace element Trace elements. two groups with COVID-19 Zinc [DOI] 10.1007/s12011-022-03400-6 PMC 바로가기
N-acetylcysteine for prevention and treatment of COVID-19: Current state of evidence and future directionsReview Published on 2022-12-012023-07-10 Journal: Journal of infection and public health [Category] COVID19(2023년), [키워드] antioxidant COVID-19 immunomodulation N-acetylcysteine SARS-CoV-2 Therapeutic role. [DOI] 10.1016/j.jiph.2022.11.009 PMC 바로가기 [Article Type] Review
Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19Research article Published on 2022-11-012022-10-05 Journal: Bioorganic chemistry [Category] SARS, 신약개발, [키워드] activities activity addition Anti-inflammatory antioxidant Cell Co-receptor consequence COVID-19 CRP derivatives DPPH Effect evaluated IL-6 infections molecular docking not correlated novel OGT Patient Pyrimidinones question raised SARS-CoV-2 screened small molecule drug tested therapy Treatment type 2 diabete type 2 diabetes [DOI] 10.1016/j.bioorg.2022.106092 [Article Type] Research article
Crystallographic study, biological assessment and POM/Docking studies of pyrazoles-sulfonamide hybrids (PSH): Identification of a combined Antibacterial/Antiviral pharmacophore sites leading to in-silico screening the anti-Covid-19 activityResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] acting activities addition Antimicrobial/Antioxidant bioactivity antioxidant Antiviral approach Bioavailability bioinformatics Compound compounds Delta derivative docking result docking study enzyme evaluated exhibited Free radicals identification Identification of the pharmacophore sites in vitro in-silico information Interaction microorganisms mutants NMR omicron Osiris pathogenic microorganism Petra Petra/Osiris/Molinspiration (POM) analyses pharmacophores PROTECT provided pyrazole Pyrazole Linked Sulfonamide Conjugates shown Structure synergistic target protein tested Toxicity X-ray diffraction [DOI] 10.1016/j.molstruc.2022.133605 [Article Type] Research article
Screening and evaluation of cytotoxicity and antiviral effects of secondary metabolites from water extracts of Bersama abyssinica against SARS-CoV-2 DeltaArticle Published on 2022-10-262022-11-15 Journal: BMC Complementary Medicine and Therapies [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Acetate activities Analysis Anti-viral anti-viral agents antioxidant antiviral activity Antiviral effect Asthma bacterial respiratory infections Bersama abyssinica bioactive compounds bronchitis BSL-3 component Compound Concentration conducted coronavirus Coviba Dawa COVID-19 COVID-19 symptoms cytotoxicity Delta delta variant determine ether experiment fraction in vitro ingredient Isolation level 3 medication methanol Phenols polar procedure propionate Registered respiratory disorder SARS-CoV-2 Screening Secondary Metabolite Standard Tanzania temperature tested the SARS-CoV-2 Traditional Traditional medicine. treat VERO E6 cells viral pathogen virus was done was obtained water [DOI] 10.1186/s12906-022-03754-3 PMC 바로가기
Inhibition of the Cell Uptake of Delta and Omicron SARS-CoV-2 Pseudoviruses by N-Acetylcysteine Irrespective of the Oxidoreductive EnvironmentArticle Published on 2022-10-212022-11-16 Journal: Cells [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2-expressing cell ACE2-expressing cells addition Affect alteration angiotensin-converting enzyme 2 antioxidant approach ascorbic acid binding Cell cell internalization cell receptor Comorbidities COVID-19 Delta dose-dependent Effect Effects Environment evaluated hydrogen peroxide inhibit inhibited inhibition mechanism N-acetyl-L-cysteine N-acetylcysteine NAC omicron Oxidant pharmacological Previous studies produced pseudovirus reactive oxygen species Reactive oxygen species. reactive oxygen specy respiratory viral infection risk ROS SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike therapy uptake variant variants variants of SARS-CoV-2 virus uptake [DOI] 10.3390/cells11203313 PMC 바로가기